Collection HTAN-VANDERBILT
Details
Subject Count: 30
Primary Site: Colon
Image Modalities: SM
Cancer Type(s): Colon Precancer
Species: Human
DOIs
HTAN-VANDERBILT original data:
Description
Colorectal cancer (CRC) is among the top three most prevalent cancers in global incidence and mortality. Most of these cancers develop from pre-cancerous adenomas. There is an unmet need to develop new preventive strategies and risk stratification models to decrease incidence, improve early detection, and prevent deaths from CRC.
We believe that the ability to provide the most effective precision diagnostics and preventive strategies can only be achieved with single-cell analysis. As such, we will map spatial relationships across the spectrum of normal colon, early polyps, and late adenomas, including their unique stromal and microbial microenvironments to identify unique molecular phenotypes.
Our goal will be accomplished through prospective, standardized collection and analysis of colorectal tissue, associated biospecimens, and related clinical and epidemiological data from participants undergoing colonoscopy or surgical resection. The biospecimens from these participants will be used for single-cell RNA sequencing, whole exome sequencing, multiplex immunofluorescence, species-specific bacterial fluorescence in situ hybridization, and other approaches. Finally, the information from these approaches will be integrated to develop a single-cell pre-cancer atlas with defined molecular phenotypes for dissemination to the broader scientific community.
Please see the DICOM converted Slide Microscopy images for the HTAN-Vanderbilt collection information page to learn more about the images and to obtain any supporting metadata for this collection.