Collection TCGA-CHOL
Details
Subject Count: 51
Primary Site: Bile Duct
Image Modalities: SM
Cancer Type(s): Cholangiocarcinoma
Species: Human
DOIs
TCGA-CHOL original data:
Description
Cholangiocarcinoma is a cancer that develops in the bile duct. The bile duct is a network of tubes that carry bile from the liver and gallbladder to the small intestine. Tumors that start in bile duct branches that lie inside the liver are called intrahepatic bile duct cancer, while those that form outside the liver are called extrahepatic bile duct cancer. About 10% of all cholangiocarcinoma are intrahepatic and 90% are extrahepatic. TCGA studied both subtypes of cholangiocarcinoma.
Although cholangiocarcinoma is a rare cancer, the incidence and mortality rates for the disease have been increasing worldwide in the last three decades. Between 2,000 and 3,000 Americans are diagnosed with cholangiocarcinoma each year, the majority of them with tumors at advanced stages. This cancer is more prevalent in Asia and the Middle East, where parasitic infection of the bile duct increases the risk of cholangiocarcinoma. Other diseases of the bile duct or liver, such as bile duct stones and liver disease, obesity, diabetes, and smoking are also risk factors. When intrahepatic and extrahepatic cholangiocarcinoma spread to other parts of the body, only 2% of patients survive five years after diagnosis.
Please see the DICOM converted Slide Microscopy images for the TCGA-CHOL collection page to learn more about the histopathology images and to obtain any supporting metadata for this collection.